2024
Probiotic Treatment of Ulcerative Colitis with Trichuris suis ova: A Randomized, Double-blinded, Placebo-controlled Clinical Trial (the PROCTO Trial)
Prosberg MV, Halkjær SI, Lo B, Bremerskov-Köser C, Ilvemark JFKF, Seidelin JB, Kristiansen MF, Kort A, Kallemose T, Bager P, Bendtsen F, Nordgaard-Lassen I, Kapel HS, Kringel H, Kapel CMO, Petersen AM. J Crohns Colitis. 2024 Jun 20:jjae095. doi: 10.1093/ecco-jcc/jjae095. Epub ahead of print. PMID: 38899778.
The effect of non-pooled multi-donor faecal microbiota transplantation for inducing clinical remission in patients with chronic pouchitis: Results from a multicentre randomised double-blinded placebo-controlled trial (MicroPouch)
Kousgaard SJ, Cold F, Halkjær SI, Petersen AM, Kjeldsen J, Møller Hansen J, Dall SM, Albertsen M, Nielsen HL, Kirk KF, Duch K, Sønderkær M, Thorlacius-Ussing O. J Crohns Colitis. 2024 May 6:jjae066. doi: 10.1093/ecco-jcc/jjae066. Epub ahead of print. PMID: 38708959.
Multi-strain probiotics during pregnancy in women with obesity influence infant gut microbiome development: results from a randomized, double-blind placebo-controlled study
Halkjær SI, Refslund Danielsen M, de Knegt VE, Andersen LO, Stensvold CR, Nielsen HV, Mirsepasi-Lauridsen HC, Krogfelt KA, Cortes D, Petersen AM. Gut Microbes. 2024 Jan-Dec;16(1):2337968. doi: 10.1080/19490976.2024.2337968. Epub 2024 Apr 9. PMID: 38591920; PMCID: PMC11005804.
The association between bacteriuria and adverse pregnancy outcomes: a systematic review and meta-analysis of observational studies
Piazzolla HRW, Modin F, Halkjær SI, Petersen AM, Calum H, Holm A. J Antimicrob Chemother. 2024 Feb 1;79(2):241-254. doi: 10.1093/jac/dkad374. PMID: 38073146.
2023
No effect of multi-strain probiotic supplementation on metabolic and inflammatory markers and newborn body composition in pregnant women with obesity: Results from a randomized, double-blind placebo-controlled study
Halkjær SI, de Knegt VE, Kallemose T, Jensen JB, Cortes D, Gluud LL, Wewer Albrechtsen NJ, Petersen AM. Nutr Metab Cardiovasc Dis. 2023 Dec;33(12):2444-2454. doi: 10.1016/j.numecd.2023.07.030. Epub 2023 Jul 28. PMID: 37580231.
Lacticaseibacillus rhamnosus GG Versus Placebo for Eradication of Vancomycin-Resistant Enterococcus faecium in Intestinal Carriers: A Systematic Review and Meta-Analysis
Rubin IMC, Knudsen MJS, Halkjær SI, Ilsby CS, Pinholt M, Petersen AM. Microorganisms. 2023 Nov 19;11(11):2804. doi: 10.3390/microorganisms11112804. PMID: 38004815; PMCID: PMC10673360.
Antibiotic-free vaginal microbiota transplant with donor engraftment, dysbiosis resolution and live birth after recurrent pregnancy loss: a proof of concept case study
Wrønding T, Vomstein K, Bosma EF, Mortensen B, Westh H, Heintz JE, Mollerup S, Petersen AM, Ensign LM, DeLong K, van Hylckama Vlieg JET, Thomsen AB, Nielsen HS. EClinicalMedicine. 2023 Jun 26;61:102070. doi: 10.1016/j.eclinm.2023.102070. PMID: 37528843; PMCID: PMC10388571.
Fecal microbiota transplantation for the treatment of irritable bowel syndrome: A systematic review and meta-analysis
Halkjær SI, Lo B, Cold F, Højer Christensen A, Holster S, König J, Brummer RJ, Aroniadis OC, Lahtinen P, Holvoet T, Gluud LL, Petersen AM. World J Gastroenterol. 2023 May 28;29(20):3185-3202. doi: 10.3748/wjg.v29.i20.3185. PMID: 37346153; PMCID: PMC10280798.
Complete Genome Sequences of Extraintestinal Pathogenic Escherichia coli Clinical Isolates from Danish Ulcerative Colitis Patients
Meski S, Struve C, Mirsepasi-Lauridsen HC, Petersen AM, Jelsbak L, Skovgaard O, Krogfelt KA. Microbiol Resour Announc. 2023 Feb 16;12(2):e0118622. doi: 10.1128/mra.01186-22. Epub 2023 Jan 30. PMID: 36715532; PMCID: PMC9933702.
2022
The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent Clostridioides difficile Infection: A Retrospective Cohort Study
Svensson CK, Cold F, Ribberholt I, Zangenberg M, Mirsepasi-Lauridsen HC, Petersen AM, Helms M. Cells. 2022 Oct 18;11(20):3272. doi: 10.3390/cells11203272. PMID: 36291139; PMCID: PMC9600246.
Synbiotic Intervention with Lactobacilli, Bifidobacteria, and Inulin in Healthy Volunteers Increases the Abundance of Bifidobacteria but Does Not Alter Microbial Diversity
Rubin IMC, Mollerup S, Broholm C, Baker A, Holm MKA, Pedersen MS, Pinholt M, Westh H, Petersen AM. Appl Environ Microbiol. 2022 Oct 11;88(19):e0108722. doi: 10.1128/aem.01087-22. Epub 2022 Sep 27. PMID: 36165644; PMCID: PMC9552601.
Gastrointestinal dysbiosis and Escherichia coli pathobionts in inflammatory bowel diseases
Petersen AM. APMIS. 2022 Aug;130 Suppl 144(Suppl 144):1-38. doi: 10.1111/apm.13256. PMID: 35899316; PMCID: PMC9546507.
No Effect of Lactobacillus rhamnosus GG on Eradication of Colonization by Vancomycin-Resistant Enterococcus faecium or Microbiome Diversity in Hospitalized Adult Patients
Rubin IMC, Mollerup S, Broholm C, Knudsen SB, Baker A, Helms M, Holm MKA, Kallemose T, Westh H, Dahl Knudsen J, Pinholt M, Petersen AM. Microbiol Spectr. 2022 Jun 29;10(3):e0234821. doi: 10.1128/spectrum.02348-21. Epub 2022 Apr 27. PMID: 35475684; PMCID: PMC9241610.
Substantial Intestinal Microbiota Differences Between Patients With Ulcerative Colitis From Ghana and Denmark
Mirsepasi-Lauridsen HC, Vranckx K, Nielsen HV, Andersen LO, Archampong T, Krogfelt KA, Petersen AM. Front Cell Infect Microbiol. 2022 Mar 3;12:832500. doi: 10.3389/fcimb.2022.832500. PMID: 35372093; PMCID: PMC8965593.
Bacteraemia caused by Lactobacillus rhamnosus given as a probiotic in a patient with a central venous catheter: a WGS case report
Rubin IMC, Stevnsborg L, Mollerup S, Petersen AM, Pinholt M. Infect Prev Pract. 2022 Jan 10;4(1):100200. doi: 10.1016/j.infpip.2022.100200. PMID: 35146406; PMCID: PMC8802096.
Successful treatment of Clostridioides difficile infection with single-donor faecal microbiota transplantation capsules
Cold F, Svensson CK, Christensen AH, Günther S, Petersen AM, Hansen LH, Helms M. Dan Med J. 2022 Jan 20;69(2):A09210712. PMID: 35088703.
Long-Term Safety Following Faecal Microbiota Transplantation as a Treatment for Recurrent Clostridioides difficile Infection Compared with Patients Treated with a Fixed Bacterial Mixture: Results from a Retrospective Cohort Study
Cold F, Svensson CK, Petersen AM, Hansen LH, Helms M. Cells. 2022 Jan 27;11(3):435. doi: 10.3390/cells11030435. PMID: 35159245; PMCID: PMC8834574.
2021
Systematic review with meta-analysis: encapsulated faecal microbiota transplantation - evidence for clinical efficacy
Cold F, Baunwall SMD, Dahlerup JF, Petersen AM, Hvas CL, Hansen LH. Therap Adv Gastroenterol. 2021 Aug 31;14:17562848211041004. doi: 10.1177/17562848211041004. PMID: 34484424; PMCID: PMC8414624.
The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome: results from a randomised, double-blind, placebo-controlled study
Madsen AMA, Halkjær SI, Christensen AH, Günther S, Browne PD, Kallemose T, Hansen LH, Petersen AM. Scand J Gastroenterol. 2021 Jul;56(7):761-769. doi: 10.1080/00365521.2021.1915375. Epub 2021 May 17. PMID: 34000958.
Fecal microbiota transplantation in hepatic encephalopathy: a systematic review
Madsen M, Kimer N, Bendtsen F, Petersen AM. Scand J Gastroenterol. 2021 May;56(5):560-569. doi: 10.1080/00365521.2021.1899277. Epub 2021 Apr 10. PMID: 33840331.
Randomised clinical trial: a 12-strain bacterial mixture versus faecal microbiota transplantation versus vancomycin for recurrent Clostridioides difficile infections
Rode AA, Chehri M, Krogsgaard LR, Heno KK, Svendsen AT, Ribberholt I, Helms M, Engberg J, Schønning K, Tvede M, Andersen CØ, Jensen US, Petersen AM, Bytzer P. Aliment Pharmacol Ther. 2021 May;53(9):999-1009. doi: 10.1111/apt.16309. Epub 2021 Mar 10. PMID: 33694229.
Pre-clinical evaluation of the effect of co-medication with antibiotics and oral steroids in Göttingen Minipigs on the biological activity of the probiotic medicinal product TSO (Trichuris suis ova)
Prosberg MV, Kringel H, Kapel JS, Kapel BS, Fredensborg BL, Petersen AM, Hansen LH, Nielsen DS, Kapel HS, Jacobsen KR, Mikkelsen LF, Kapel CMO. Parasitol Res. 2021 Feb;120(2):743-746. doi: 10.1007/s00436-020-07004-8. Epub 2021 Jan 6. PMID: 33409625.
Engraftment of strictly anaerobic oxygen-sensitive bacteria in irritable bowel syndrome patients following fecal microbiota transplantation does not improve symptoms
Browne PD, Cold F, Petersen AM, Halkjær SI, Christensen AH, Günther S, Hestbjerg Hansen L. Gut Microbes. 2021 Jan-Dec;13(1):1-16. doi: 10.1080/19490976.2021.1927635. PMID: 34074214; PMCID: PMC8183560.
2020
Fecal Microbiota Transplantation in the Treatment of Chronic Pouchitis: A Systematic Review
Cold F, Kousgaard SJ, Halkjaer SI, Petersen AM, Nielsen HL, Thorlacius-Ussing O, Hansen LH. Microorganisms. 2020 Sep 18;8(9):1433. doi: 10.3390/microorganisms8091433. PMID: 32962069; PMCID: PMC7565999.
Multistrain Probiotic Increases the Gut Microbiota Diversity in Obese Pregnant Women: Results from a Randomized, Double-Blind Placebo-Controlled Study
Halkjær SI, de Knegt VE, Lo B, Nilas L, Cortes D, Pedersen AE, Mirsepasi-Lauridsen HC, Andersen LO, Nielsen HV, Stensvold CR, Johannesen TB, Kallemose T, Krogfelt KA, Petersen AM. Curr Dev Nutr. 2020 May 27;4(7):nzaa095. doi: 10.1093/cdn/nzaa095. PMID: 32617453; PMCID: PMC7319727.
High Abundance of Proteobacteria in Ileo-Anal Pouch Anastomosis and Increased Abundance of Fusobacteria Associated with Increased Pouch Inflammation
Petersen AM, Mirsepasi-Lauridsen HC, Vester-Andersen MK, Sørensen N, Krogfelt KA, Bendtsen F. Antibiotics (Basel). 2020 May 8;9(5):237. doi: 10.3390/antibiotics9050237. PMID: 32397087; PMCID: PMC7277091.
Effect of α-Hemolysin Producing E. coli in Two Different Mouse Strains in a DSS Model of Inflammatory Bowel Disease
Mirsepasi-Lauridsen HC, Struve C, Petersen AM, Krogfelt KA. Microorganisms. 2020 Dec 11;8(12):1971. doi: 10.3390/microorganisms8121971. PMID: 33322398; PMCID: PMC7764192.
2019
Increased abundance of proteobacteria in aggressive Crohn's disease seven years after diagnosis
Vester-Andersen MK, Mirsepasi-Lauridsen HC, Prosberg MV, Mortensen CO, Träger C, Skovsen K, Thorkilgaard T, Nøjgaard C, Vind I, Krogfelt KA, Sørensen N, Bendtsen F, Petersen AM. Sci Rep. 2019 Sep 17;9(1):13473. doi: 10.1038/s41598-019-49833-3. PMID: 31530835; PMCID: PMC6748953.
Multidonor FMT capsules improve symptoms and decrease fecal calprotectin in ulcerative colitis patients while treated - an open-label pilot study
Cold F, Browne PD, Günther S, Halkjaer SI, Petersen AM, Al-Gibouri Z, Hansen LH, Christensen AH. Scand J Gastroenterol. 2019 Mar;54(3):289-296. doi: 10.1080/00365521.2019.1585939. Epub 2019 Apr 4. PMID: 30946615.
Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease
Mirsepasi-Lauridsen HC, Vallance BA, Krogfelt KA, Petersen AM. Clin Microbiol Rev. 2019 Jan 30;32(2):e00060-18. doi: 10.1128/CMR.00060-18. PMID: 30700431; PMCID: PMC6431131.
2018
Disease-Specific Enteric Microbiome Dysbiosis in Inflammatory Bowel Disease
Mirsepasi-Lauridsen HC, Vrankx K, Engberg J, Friis-Møller A, Brynskov J, Nordgaard-Lassen I, Petersen AM, Krogfelt KA. Front Med (Lausanne). 2018 Nov 20;5:304. doi: 10.3389/fmed.2018.00304. PMID: 30525037; PMCID: PMC6256240.
Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study
Halkjær SI, Christensen AH, Lo BZS, Browne PD, Günther S, Hansen LH, Petersen AM. Gut. 2018 Dec;67(12):2107-2115. doi: 10.1136/gutjnl-2018-316434. Epub 2018 Jul 6. PMID: 29980607.
Use of prophylactic Saccharomyces boulardii to prevent Clostridium difficile infection in hospitalized patients: a controlled prospective intervention study
Carstensen JW, Chehri M, Schønning K, Rasmussen SC, Anhøj J, Godtfredsen NS, Andersen CØ, Petersen AM. Eur J Clin Microbiol Infect Dis. 2018 Aug;37(8):1431-1439. doi: 10.1007/s10096-018-3267-x. Epub 2018 May 3. PMID: 29725956.
Case series of successful treatment with fecal microbiota transplant (FMT) oral capsules mixed from multiple donors even in patients previously treated with FMT enemas for recurrent Clostridium difficile infection
Chehri M, Christensen AH, Halkjær SI, Günther S, Petersen AM, Helms M. Medicine (Baltimore). 2018 Aug;97(31):e11706. doi: 10.1097/MD.0000000000011706. PMID: 30075573; PMCID: PMC6081131.
Probiotika til forebyggelse af Clostridium difficile-infektion
Petersen AM. Ugeskr Laeger. 2018 Jul 9;180(28):V69867. Danish. PMID: 29984700.
Review of Saccharomyces boulardii as a treatment option in IBD
Sivananthan K, Petersen AM. Immunopharmacol Immunotoxicol. 2018 Dec;40(6):465-475. doi: 10.1080/08923973.2018.1469143. Epub 2018 May 17. PMID: 29771163.
2017
Faecal microbiota transplantation for the treatment of bowel disease
Rode AA, Chehri M, Petersen AM, Bytzer P. Ugeskr Laeger. 2017 Jul 31;179(31):V03170218. Danish. PMID: 28869008.
Can fecal microbiota transplantation cure irritable bowel syndrome?
Halkjær SI, Boolsen AW, Günther S, Christensen AH, Petersen AM. World J Gastroenterol. 2017 Jun 14;23(22):4112-4120. doi: 10.3748/wjg.v23.i22.4112. PMID: 28652664; PMCID: PMC5473130.
A Randomised, Double-blind, Placebo-controlled Trial of Trichuris suis ova in Active Crohn's Disease
Schölmerich J, Fellermann K, Seibold FW, Rogler G, Langhorst J, Howaldt S, Novacek G, Petersen AM, Bachmann O, Matthes H, Hesselbarth N, Teich N, Wehkamp J, Klaus J, Ott C, Dilger K, Greinwald R, Mueller R; International TRUST-2 Study Group. J Crohns Colitis. 2017 Apr 1;11(4):390-399. doi: 10.1093/ecco-jcc/jjw184. PMID: 27707789; PMCID: PMC5881737.
2016
The association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis
Prosberg M, Bendtsen F, Vind I, Petersen AM, Gluud LL. Scand J Gastroenterol. 2016 Dec;51(12):1407-1415. doi: 10.1080/00365521.2016.1216587. Epub 2016 Aug 9. PMID: 27687331.
Effects of probiotics (Vivomixx®) in obese pregnant women and their newborn: study protocol for a randomized controlled trial
Halkjaer SI, Nilas L, Carlsen EM, Cortes D, Halldórsson TI, Olsen SF, Pedersen AE, Krogfelt KA, Petersen AM. Trials. 2016 Oct 11;17(1):491. doi: 10.1186/s13063-016-1617-5. PMID: 27724923; PMCID: PMC5057415.
Extraintestinal pathogenic Escherichia coli are associated with intestinal inflammation in patients with ulcerative colitis
Mirsepasi-Lauridsen HC, Halkjaer SI, Mortensen EM, Lydolph MC, Nordgaard-Lassen I, Krogfelt KA, Petersen AM. Sci Rep. 2016 Sep 30;6:31152. doi: 10.1038/srep31152. PMID: 27686530; PMCID: PMC5043179.
Secretion of Alpha-Hemolysin by Escherichia coli Disrupts Tight Junctions in Ulcerative Colitis Patients
Mirsepasi-Lauridsen HC, Du Z, Struve C, Charbon G, Karczewski J, Krogfelt KA, Petersen AM, Wells JM. Clin Transl Gastroenterol. 2016 Mar 3;7(3):e149. doi: 10.1038/ctg.2016.3. PMID: 26938480; PMCID: PMC4822097.
2015
Distinct inflammatory and cytopathic characteristics of Escherichia coli isolates from inflammatory bowel disease patients
Jensen SR, Mirsepasi-Lauridsen HC, Thysen AH, Brynskov J, Krogfelt KA, Petersen AM, Pedersen AE, Brix S. Int J Med Microbiol. 2015 Dec;305(8):925-36. doi: 10.1016/j.ijmm.2015.10.002. Epub 2015 Oct 22. PMID: 26522075.
Intestinal colonization with phylogenetic group B2 Escherichia coli related to inflammatory bowel disease: a systematic review and meta-analysis
Petersen AM, Halkjær SI, Gluud LL. Scand J Gastroenterol. 2015;50(10):1199-207. doi: 10.3109/00365521.2015.1028993. Epub 2015 Apr 24. PMID: 25910859.
2014
Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: a double-blind randomized placebo controlled clinical trial
Petersen AM, Mirsepasi H, Halkjær SI, Mortensen EM, Nordgaard-Lassen I, Krogfelt KA. J Crohns Colitis. 2014 Nov;8(11):1498-505. doi: 10.1016/j.crohns.2014.06.001. Epub 2014 Jun 25. PMID: 24972748.