Medication

​​​

Background

Medication in the older population is a complex field. The aging process is associated with physiological changes such as a decrease in hepatic clearance, a decrease in glomerular filtration capacity, loss of total muscle mass and impaired homeostatic mechanisms. These changes have an impact on the pharmacodynamics and –kinetics, which increases the risk of adverse drug reactions in older people.

Medication for the older population is becoming a noticeable problem as the average life expectancy is increasing. The prevalence of older persons with multiple (chronic) diseases, increases the chance of poly-pharmacy. Further, older persons are frequently admitted to hospitals; this increases the complexity of handling drugs to older people between the primary and secondary sector. 

Main Focus 

Our main focus has been on Potentially Inappropriate Medications (PIMs), which are drugs which carry more risks than benefits for older people. PIMs and poly-pharmacy expose older people to a greater risk of adverse drug reactions.

Further we have looked at the implementation of Shared Medication Card (in Danish: KMK - Fælles Medicin Kort), which is a new computer system to handling medicine. 

Ongoing studies

Patient's kidney function is important when prescribing renal risk drugs  due to the increased risk of toxicity and adverse reactions. Kidney function is typically estimated from the level of biomarkers in the blood, which may be more or less dependent on muscle mass. Hence, accurate estimation of kidney function may be challenged in patients undergoing lower extremity amputation. We investigate if the estimation of kidney function change before and after amputation and what the consequences are for dosing of prescribed renal risk drugs. Project leaders: Morten B. Houlind and Charlotte Treldal.

Publications

Physicians' Non-Uniform Approach to Prescribing Drugs to Older Patients - A Qualitative Study. Christensen, L. D., Petersen, J., Andersen, O. & Kaae, S. 1 dec. 2017 I : Basic & clinical pharmacology & toxicology. 121, 6, s. 505-511.

Bedside lockers for bedside medication in hospital. Houlind M.B, Treldal C, Olsen S.S, Thomsen A.F, Andersen O, Mogensen T.S, Mcnulty H. Hospital Drift & Arkitektur 2016 Nov; 8: 6-7.

Mobile meditation units facilitate bedside meditation in hospital. Andersen MB, Treldal C, Gemmer M, Gede DB, Andersen S, Kjeldsen LJ, Mogensen TS, Mcnulty H. Hospital Drift & Arkitektur 2016 Aug; 5: 8-9.

Potentially inappropriate medication related to weakness in older acute medical patients. Jensen, L. D., Andersen, O., Hallin, M. & Petersen, J. 11 apr 2014 I : International Journal of Clinical Pharmacy. 36, 3, s. 570-580.

Implementering af fælles medicinkort er vanskeligt. Christensen, S., Jensen, L. D., Kaae, S., Vinding, K. L. & Petersen, J. 21 jul 2014 I : Ugeskrift for Laeger. 176, 15, s. 1389-1391.

Initial Impressions of One-Stop Dispensing (OSD) at a Danish In-Patient Unit. Andersen M.B, Olsen S.S, Kirketerp-Moller K, McNulty H. Sygeplejersken 2014;(13):86-8.


Redaktør