Biological aging and Chronic Inflammation

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​Background 

From the 3rd decade in life, almost all parts of our body have an ongoing declining capacity. This includes our: immune system, brain, muscles, aerobic capacity and bones. The consequences are inevitable: - dependence on help from others and vulnerability/ fragility. The age where we reach this state in life depends on the speed of the aging process. In some people, this process is accelerated; that is, they age prematurely turning “old” at an early age. The speed of the ageing process is related to several causes such as life style, genetics, illness etc. which may interact synergistically. 

Main focus 

Our main focus is to identify and understand low functional level and accelerated functional decline in the older person by measures of cognitive function, muscle strength, basic mobility, functional independency and immunological biomarkers. 

We believe that acutely admitted older medical patient is essential to this research. 

On-going studies 

Defining chronic inflammation. Definition of chronic inflammation and development of chronic inflammation risk score. Register-based study using biomarker data from the Danish population-based studies Inter99 (n=5,538) and Monica10 (n=2,602) to develop models for chronic inflammation as a pre-pathological process, predictive of chronic diseases and premature mortality. Project leader: Line Jee Hartmann Rasmussen.


Mechanisms of chronic inflammation and biological aging (part of the FAM-CPH study). Cross-sectional and longitudinal investigation of differences in chronic inflammation and biological age between acutely admitted and healthy persons above 65 years, and between younger and older persons. Immune cells will be investigated with flow cytometry (NF-κB and NLRP3 inflammasome activity) and ELISA and Luminex (cytokines) methods. Patients have been included and inclusion of controls is on-going. Project leaders: Juliette Tavenier, Line Jee Hartmann Rasmussen.

MicroRNAs as biomarkers of biological aging.
MicroRNAs as biomarkers of biological aging in acutely admitted elderly patients. Screening of microRNAs in patients from the DISABLMENT study (acutely admitted patients above 65 years, n=369) to identify a profile of microRNAs associated with biological aging (assessed using physical, physiological, cognitive, and immunological markers, and mortality). The microRNA-profile will be validated in the FAM-CPH study. Project leader: Juliette Tavenier.

The MULTI-study. Epidemiological strategies aiming to adapt trajectories for older people with multimorbidity: a national register-based study and a prospective clinical cohort study to investigate the hypothesis that older persons can be grouped into homogeneous patterns of multimorbidity, and that these patterns are related to the ageing process, with the use of latent class models. Study 1: Prevalence and overlap of Disease Management Program diseases in older hospitalized patients. Study 2: Ageing process among acutely admitted older medical patients (≥ 65 years) – an explorative latent variable model of multimorbidity: a prospective cohort study. 369 patients will be enrolled. Study 3: Development of patterns of multimorbidity in Denmark among older people (≤ 65 years) – a nationwide registry study. Project leader: Helle Gybel Juul-Larsen.

Publications

Prevalence and overlap of Disease Management Program diseases in older hospitalized patients. Juul-Larsen, H. G., Petersen, J., Sivertsen, D. M., & Andersen, O. (2017). European Journal of Ageing14(3), 283–293. http://doi.org/10.1007/s10433-017-0412-9

Low-dose growth hormone therapy reduces inflammation in HIV-infected patients: a randomised placebo controlled study. Lindboe JB, Langkilde A, Eugen-Olsen J, Hansen BR, Haupt TH, Petersen J, Andersen O. Infect Dis (Lond)

Plasma CD163 independently predicts all-cause mortality from HIV-1 infection. Knudsen TB, Ertner G, Petersen J, Møller HJ, Moestrup SK, Eugen-Olsen J, Kronborg G, Benfield T. J Infect Dis  

Prediction of Mobility Limitations after Hospitalization in Older Medical Patients by Simple Measures of Physical Performance Obtained at Admission to the Emergency Department.  Bodilsen AC,  Klausen HH , Petersen J, Beyer N , Andersen O , Jørgensen LM , Juul-Larsen HG , Bandholm T. PLoS One 2016 May 19;11(5):e0154350. doi: 10.1371/journal.pone.0154350. eCollection 2016

Stromal cell-derived factor 1α (SDF-1α): A marker of disease burden in patients with atrial fibrillation. Li, D., Bjørnager, L., Langkilde, A., Andersen, O., Jøns, C., Agner, B. F. R., Dixen, U. & Landex, N. L. 2016 I : Scandinavian cardiovascular journal : SCJ. 50, 1, s. 36-41

Letters to the Editor: Genetic polymorphism and soluble urokinase plasminogen activator receptor regulation. Rasmussen, L. J. H., Haupt, T. H., Andersen, O. & Eugen-Olsen, J. dec 2015 I : F A S E B Journal. 29, 12, s. 4757-8

Immunosenescence of the CD8(+) T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls. Tavenier, J., Langkilde, A., Haupt, T. H., Henriksen, J. H., Jensen, F. K., Petersen, J. & Andersen, O. nov 2015 I : B M C Immunology. 16, 72, s. 1-14

Leptin, IL-6, and suPAR reflect distinct inflammatory changes associated with adiposity, lipodystrophy and low muscle mass in HIV-infected patients and controls. Langkilde, A., Petersen, J., Henriksen, J. H., Jensen, F. K., Gerstoft, J., Eugen-Olsen, J. & Andersen, O. sep 2015 I : Immunity & Ageing. 12, s. 9

Assessment of in situ adipose tissue inflammation by microdialysis. Langkilde, A., Andersen, O., Henriksen, J. H., Langberg, H., Petersen, J. & Eugen-Olsen, J. mar 2015 I : Clinical physiology and functional imaging. 35, 2, s. 110

Risk factors associated with serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in a general population. Haupt, T. H., Kallemose, T., Ladelund, S., Jee Hartmann Rasmussen, L., Thorball, C. W., Andersen, O., Pisinger, C. & Eugen-Olsen, J. 2014 I : Biomarker insights. 9, s. 91-100

Life-long endurance exercise in humans: Circulating levels of inflammatory markers and leg muscle size. Mikkelsen, U. R., Couppé, C., Karlsen, A., Grosset, J. F., Schjerling, P., Mackey, A. L., Klausen, H. H., Magnusson, S. P. & Kjær, M. 2013 I : Mechanisms of Ageing and Development. 134, 11-12, s. 531-40

Inflammation in HIV-Infected Patients: Impact of HIV, Lifestyle, Body Composition, and Demography - A Cross Sectional Cohort Study. Langkilde, A., Petersen, J., Klausen, H. H., Henriksen, J. H., Eugen-Olsen, J. & Andersen, O. 2012 I : P L o S One. 7, 12, s. e51698​
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