Medication in the older population is a complex field. The aging process is associated with physiological changes such as a decrease in hepatic clearance, a decrease in glomerular filtration capacity, loss of total muscle mass and impaired homeostatic mechanisms. These changes have an impact on the pharmacodynamics and –kinetics, which increases the risk of adverse drug reactions in older people.

Medication for the older population is becoming a noticeable problem as the average life expectancy is increasing. The prevalence of older persons with multiple (chronic) diseases, increases the chance of poly-pharmacy. Further, older persons are frequently admitted to hospitals; this increases the complexity of handling drugs to older people between the primary and secondary sector.

Main Focus
Our main focus has been on Potentially Inappropriate Medications (PIMs), which are drugs which carry more risks than benefits for older people. PIMs and poly-pharmacy expose older people to a greater risk of adverse drug reactions.

Further we have looked at the implementation of Shared Medication Card (in Danish: KMK - Fælles Medicin Kort), which is a new computer system to handling medicine.

Ongoing studies
Implementering af FMK – To skridt frem og et tilbage, Selina Christensen, Line Due Jensen, Kirsten Laila Vinding and Janne Petersen [Manuscript in preparation]

Potentially Inappropriate Medications (PIM) from Specialist Doctors point of view, Line Due Jensen [Study under construction]

Finished studies
Potentially inappropriate medication related to weakness in older acute medical patients. Jensen LD, Andersen O, Hallin M, Petersen J. Int J Clin Pharm. 2014 Jun;36(3):570-80

Problems Using FMK at Discharge Seen From a Hospital Doctors’ Perspective. Title in Danish: Problemer ved brugen af det Fælles Medicinkort (FMK) ved udskrivelse set fra hospitalslægers perspektiv. Selina Christiansen [Master Thesis] University of Copenhagen, Completion date: 14. September 2012

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