Biological Ageing

Issues/Background
From the 3rd decade in life, almost all parts of our body have an ongoing declining capacity. This includes our: immune system, brain, muscles, aerobic capacity and bones. The consequences are inevitable: - dependence on help from others and vulnerability/ fragility. The age where we read this state in life depends on the speed of the aging process. In some people, this process is accelerated; that is, they age prematurely turning “old” at an early age. The speed of the ageing process is related to several causes such as life style, genetics, illness etc. which may interact synergistically.

Main focus
Our main focus is to identify and understand low functional level and accelerated functional decline in the older person by measures of cognitive function, muscle strength, basic mobility, functional independency and immunological biomarkers.

We believe that acutely admitted older medical patient is essential to this research.

On-going studies 
Identification of acutely admitted older medical patients with low functional level or at risk of functional decline. Ann Christine Bodilsen, Henrik Hedegaard Klausen [Patients are enrolled]

Reliability of measures of muscle strength, basic mobility and gait speed measured in older medical patients admitted to the acute medical department. Ann Christine Bodilsen, Helle Gybel Juul-Larsen… [Manuscript in preparation]

Finished studies 

Feasibility and Inter-Rater Reliability of Physical Performance Measures in Acutely Admitted Older Medical Patients. Bodilsen AC, Juul-Larsen HG, Petersen J, Beyer N, Andersen O, Bandholm T. PLoS One. 2015 Feb 23;10(2):e0118248

Risk factors associated with serum levels of the inflammatory biomarker soluble urokinase plasminogen activator receptor in a general population. Haupt TH, Kallemose T, Ladelund S, Jee Hartmann Rasmussen L, Thorball CW, Andersen O, Pisinger C, Eugen-Olsen J. Biomarker insights 2014;9:91-100

Outcomes in elderly Danish citizens admitted with community-acquired pneumonia. Regional differences, in a public healthcare system. Klausen HH, Petersen J, Lindhardt T, Bandholm T, Hendriksen C, Kehlet H, Vestbo J, Andersen O. Respir Med. 2012 Dec;106(12):1778-1787

Acute hospitalization of the old medical patient: Changes in muscle strength and functional performance during and 30 days after discharge. Bodilsen AC, Pedersen MM, Petersen J, Beyer N, Andersen O, Smith LL, Kehlet H, Bandholm T. Am J Phys Med Rehabil. 2013 Sep;92(9):789-96

Plasma suPAR levels are associated with mortality, admission time, and Charlson Comorbidity Index in the acutely admitted medical patient: a prospective observational study. Haupt TH, Petersen J, Ellekilde G, Klausen HH, Thorball CW, Eugen-Olsen J. & Andersen O. 2012. Critical Care. 16, 4, p. R130 

Responsible editor