Chronic infections


A chronic infection is a prolonged or persistent invasion of the body by pathogens such as viruses and bacteria. 

The research activities at AHH are aimed toward a better understanding of the mechanism behind spontaneously clearing of virus and long-term effect of having a viral infection such as follows: 

• Hepatitis C virus (HCV) 
• Human Immunodeficiency Virus (HIV) 
• Human Papillomavirus (HPV) 

Publications on the topic

Background: Around a quarter of individuals infected with hepatitis C virus (HCV) are spontaneously able to clear the virus. 

Methods: We analyzed 327 anti-HCV-positive HIV-1-infected patients using multivariate logistic regression. 

Results: We included 327 HIV-1-infected individuals. 76 had cleared their HCV infection and 251 had a chronic infection. Race, acquired immunodeficiency syndrome (AIDS), and antiretroviral therapy were not associated with HCV clearance. 

Conclusions: The HCV clearance rate in this HIV-1 cohort was 23%. Our data suggest an interaction of hepatitis B virus and HCV that influences the outcome of acute HCV infection. 

Patterns of cervical human papillomavirus (HPV) infection suggest that HPV genotypes are not independent of each other. This may be explained by risk factors common to all HPV infections, but type-specific biological factors may also play a role. 

This raises the question of whether widespread use of the quadrivalent vaccine (covering HPV6, 11, 16, 18) may indirectly affect the prevalence of any non-vaccine types. 
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