Inflammatory bowel diseases

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The research in inflammatory bowel diseases is centered on understanding the autoimmune syndrome behind the two main forms:

  • Chrohn’s disease which effects any part of the gastrointestinal tract
  • Ulcerative Colitis - restricted to the colon and the rectum

The research projects develop and combine new medical and surgical treatment regimens along with testing biomarkers for their ability to predict treatment outcome and prognosis.
 
Publication on the topic

Seroreactivity to E. coli outer membrane protein C antibodies in active inflammatory bowel disease; diagnostic value and correlation with phylogroup B2 E. coli infection

Background: Several serologic tests, including anti-outer membrane porin C antibody (Omp C), are used for screening and as marker of disease course in inflammatory bowel diseases (IBD).

Conclusions: Omp C titer was not raised in patients with active IBD compared with patients in remission. In addition, there was no difference in Omp C level in patients with active Crohn's disease compared with controls. These observations do not support the use of Omp C serology testing, either in disease activity assessment, or in screening for active Crohn's disease.

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